Ophthalmology Pipeline Represents a Paradigm Shift in Treatment
THE NEED
- Over 10M eye injections per year = Heavy treatment burden on patients and doctors
- Approved and prospective drugs require a retinal ophthalmologist, a caregiver to drive to/from visits, and an expensive treatment
OUR SOLUTION
- Patient administers drug at home with autoinjector subcutaneously up to once per month (potential for oral administration)
- Market Research = > $3.5 B peak US sales
51 US retinal ophthalmologists, 5 payers
Discount to Eylea, rebates, market access (conservative)
Patient market research ongoing
- Lower cost – manufactured at up to 1/10 the cost of other approaches
HD Targets Ocular Neovascularization After Systemic Dose

- After systemic dose, uptake ONLY in activated cells in regions of inflammation
- Crosses blood retinal barrier in monkeys, mice & rats

D-4517.2: First-in-Class Home Administered Wet AMD Therapy
Mouse Laser CNV Model: Single Subcutaneous or Oral D-4517.2 Dose on Day 1

Once Every 2+ Weeks or Oral
D-4517.2 at 2 mg/kg (40 µg) subcutaneous (SC) dose equivalent to Eylea (aflibercept) intravitreal (IVT) dose (40 µg) at Day 14
Oral D-4517.2 doses equally or more effective
Human doses to achieve equivalent effect are safe and well tolerated
Our Approach
- Patient administers drug at home with autoinjector up to once per month
(potential for oral administration)
Market Expansion
- Patients in rural areas receive convenient treatment (especially parts of China and India)
- Diabetic patients maintain compliance (treated for decades)
- Treatment of earlier stage of AMD
- Lower cost – manufactured at up to 1/10 the cost of other approaches
D-4517 Alters Pharmacology through Non-Cleavable Dendrimer
Sunitinib (Sutent™) | D-4517 |
Liver toxicity (decreased size/increased ALT/AST) | No observed effect |
Proteinuria, decrease in kidney size (males) | No observed effect |
Hypoglycemia (females) | No observed effect |
Decrease in heart size (males) | No observed effect |
Same sunitinib exposure in both groups
D-4517
proprietary Sunitinib analog

D-4517.2: Safety Established in Healthy Humans
Phase 1, Single Dose – SC Doses Up to 1 mg/kg
Study Objectives:
Complete safety, PK, metabolism, clearance and safety of single SC dose administration in adult subjects
Study Results Summary:
- Safe and well tolerated with only mild transient injection site reactions in a few patients (technique related)
- No changes in safety labs
- PK translates to effective doses in preclinical models
D-4517.2: Phase 2 Proof of Concept in Wet AMD and DME Patients
Two Stage Design
Stage 1 of Phase 2:
- Safety, pharmacodynamics, and durability of subcutaneous D-4517.2 compared to Intravitreal aflibercept in wet AMD and DME Patients
(Aflibercept to D-4517.2 crossover design in same patient) (30 patients)
Stage 2 of Phase 2:
- Randomized, placebo/sham controlled, double masked non-inferior study comparing subcutaneous D-4517.2 to aflibercept (270 wet AMD patients)
TIMELINES
Stage 1, Phase 2 LPI in 1H 2023
- Stage 1, Phase 2 data in 2H 2023
Stage 2, Phase 2 FPI in 2024
Launch wet AMD Stage 2 and Separate DME Phase 2 in Parallel
Projected Product Launch = 2028
D-4517.2 Commercial Assessment
