How do HDTs work?

Disease Cell-targeted Precision Medicine

Disease Cell-targeted Precision Medicine

Precise Targeting to Disease Tissues Eliminating Toxicity to Improve Patient Outcomes

HDs Have All the Characteristics of an Ideal Targeted Drug Platform

Efficient Product Engine

Engine Rapidly Delivers Breakthrough Therapies
Opening Therapeutic Window
Disrupting the Drug Development Paradigm

Selective Uptake

Tumor Associated Macrophages

Crosses Tissue Barriers

blood/retinal barrier vs. blood/brain barrier

Tunable for Each Indication and Small Molecule Drug

Nance 2016; Zhang 2016

Simple, Elegant Physics Based Targeting

Endocytosis Rate >> Rate of Diffusion/Flow Past Cells in Region of Inflammation