How do HDTs work?
Disease Cell-targeted Precision Medicine
Precise Targeting to Disease Tissues Eliminating Toxicity to Improve Patient Outcomes
HDs Have All the Characteristics of an Ideal Targeted Drug Platform
- Selective Uptake – only by reactive inflammatory cells in diseased tissue (w/o ligand)
- Systemic Delivery – oral or injectable
- Crosses Tissue Barriers – blood/brain; blood/retinal
- Lack of Off-target Toxicity – safe at high doses
- Sustained Intracellular Effects – weeks to months
- Tunable for Each Indication and Small Molecule Drug
- Low-cost Manufacture – and rapid discovery process
Efficient Product Engine
Selective Uptake
Crosses Tissue Barriers
Tunable for Each Indication and Small Molecule Drug
Nance 2016; Zhang 2016