How do nanomedicines work? Precision Nanomedicine Targeting Only Diseased Tissues Precise Targeting to Diseased Tissues Eliminating Toxicity to Improve Patient Outcomes HDs Have All the Characteristics of an Ideal Targeted Nanomedicine Selective Uptake – only by reactive inflammatory cells in diseased tissue (w/o ligand) Systemic Delivery – oral or injectable Crosses Tissue Barriers – blood/brain; blood/retinal Lack of Off-target Toxicity – safe at high doses Sustained Intracellular Effects – weeks to months Tunable for Each Indication and Target Low-cost Manufacture – and rapid discovery process Selective: Nanomedicine Uptake in Reactive and Diseased Cells